CLASSY-PEPTIDES

PT-141

CAS: 32780-32-8
Formula: C50H68N14O10
Sequence: CH3CO-Nle-[Asp-His-(d)-Phe-Arg-Trp-Lys]-COOH

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CAS: 32780-32-8
Formula: C50H68N14O10
Sequence: CH3CO-Nle-[Asp-His-(d)-Phe-Arg-Trp-Lys]-COOH

PT-141, also called as Bremelanotide, is a derivative for Melanotan 2 (M2). Unlike M2, PT-141 lacks C-terminal amide molecules. Bremelanotide is a cyclic hepta-peptide lactam derivative of alpha-MSH. PT-141 acts by stimulating melanocortin receptors present in the central nervous system. Due to this potential, PT-141 is being studied as a potential treatment for sexual disorders such as erectile disorders in men and sexual arousal disorders in women.The amino acid structure of PT-141 is Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH or cyclo-[Nle4, Asp5, D-Phe7, Lys10]alpha-MSH-(4-10). It is not a vasoactive compound, rather acts directly in the higher centers to increase sexual activity. Over 6 years, studies yielded promising results and additional studies are underway to further explore the properties of M2 derivative.